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Cyclopamine (11-Deoxojervine)

Cyclopamine (11-Deoxojervine)

Item no.	V1332-50mg
Manufacturer	InvivoChem LLC
CASRN	4449-51-8
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1332CAS #:4449-51-8Purity >=98% Description: Cyclopamine (formerly HSDB3505; HSDB-3505; 11-deoxojervine), a naturally occuring steroid alkaloid found in Veratrum plant, is reported to be a potent and specific inhibitor of Hedgehog (Hh) signaling pathway with both anticancer and teratogenic activities. It inhibits Smoothened (Smo) with an IC50 of 46 nM in TM3Hh12 cells. Description: References: Bioorg Med Chem Lett. 2009 Jan 15; 19(2):328-31; Nature. 2003 Oct 23; 425(6960):846-51. References:
Molecular Weight (MW)	411.62
Formula	C27H41NO2
CAS No.	4449-51-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO:< 1 mg/mL
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL (4.9 mM)
Solubility (In vivo)	10% DMSO+30% PEG 300+5% Tween 80+ddH2O: 1mg/mL
Synonyms	HSDB3505; 11-deoxojervine; HSDB 3505; HSDB-3505

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 9/4/2025

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