« Back
Home /
Taladegib (LY2940680)

Taladegib (LY2940680)

Item no.	V1334-100mg
Manufacturer	InvivoChem LLC
CASRN	1258861-20-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1334CAS #:1258861-20-9Purity >=98% Description: Taladegib (formerly LY2940680, LY 2940680, LY-2940680) is a potent and orally bioavailable Hedgehog pathway antagonist of the smoothened receptor being developed by Eli Lilly for the treatment of cancer. It acts by binding to the Smoothened (Smo) receptor, thus inhibiting the Hedgehog (Hh) signaling pathway. Taladegib has the potential to be used in patient with cancer who are resistant to vismodegib. Description: References: Expert Opin Investig Drugs. 2011 Dec; 20(12):1649-64. References Related CAS#: 1258861-21-0 (HCl)
Molecular Weight (MW)	512.5
Formula	C26H24F4N6O
CAS No.	1258861-20-9 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 5 mg/mL (9.8 mM)
	Water:< 1 mg/mL
	Ethanol: 2 mg/mL (3.9 mM)
Other info	Chemical Name: 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide InChi Key: SZBGQDXLNMELTB-UHFFFAOYSA-N InChi Code: InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28, 29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9, 12, 15, 17H, 10-11, 13-14H2, 1-2H3 SMILES Code: O=C(N(C)C1CCN(C2=NN=C(C3=CC=NN3C)C4=C2C=CC=C4)CC1)C5=CC=C(F)C=C5C(F)(F)F
Synonyms	LY2940680, LY 2940680, LY-2940680

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 1 days

Compare

Add to wishlist

Get an offer