Puromycin (CL13900)

Description: Puromycin (CL13900), an analog of aminoacyl-tRNA (anaminonucleoside), is a potent antibiotic which acts as a protein synthesis inhibitor. It inhibits the incorporation of aminoacyl-tRNA into the C-terminal on a synthesizing polypeptide, resulting in the premature termination of the polypeptide chain. Puromycin is toxic to the growth of various eukaryote cells including mammalian cells. Concentrations of puromycin sufficient to inhibit the cell growth of mammalian cells range from 0.5-10 ug/ml. IC90s for puromycin to inhibit the growth of Plasmodium falciparum and Giardia lamblia are 60 ng/ml and 54 ug/ml, respectively.

References: Pharmacol Rev. 1964 Sep; 16:223-43; Biol Reprod. 2005 Feb; 72(2):309-15.

Related CAS#: 53-79-2 (Puromycin free base); 58-60-6 (Puromycin Aminonucleoside)