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BMS-833923 (XL-139)

BMS-833923 (XL-139)

Item no.	V1341-100mg
Manufacturer	InvivoChem LLC
CASRN	1059734-66-5
Amount	100 mg
Quantity options	10 mg 1 g 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1341CAS #:1059734-66-5Purity >=98% Description: BMS-833923 (also known as XL139; BMS833923; XL-139; BMS 833923) is a novel, potent, selective, and orally bioavailable inhibitor of SMO (Smoothened) with potential antineoplastic activity. It inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM. BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. BMS-833923 robustly inhibits HH pathway activity with along duration of action after a single oral dose in medulloblastoma and pancreatic carcinoma xenograft models. Description: References: Cancer Invest. 2013 Aug; 31(7):480-9; Prostate. 2013 Dec; 73(16):1810-23. References:
Molecular Weight (MW)	473.57
Formula	C30H27N5O
CAS No.	1059734-66-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 95 mg/mL (200.6 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	O=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2
Synonyms	XL139; BMS833923; XL-139; BMS-833923; BMS 833923; XL 139.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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