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RKI-1447

RKI-1447

Item no.	V1346-10mg
Manufacturer	InvivoChem LLC
CASRN	1342278-01-6
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1346CAS #:1342278-01-6Purity >=98% Description: RKI-1447 (ROCK Inhibitor XIII; RKI 1447; RKI1447) is a potent small molecule inhibitor of ROCK1 and ROCK2 with potential antitumor activities against breast cancer. It inhibits ROCK1 and ROCK2 with IC50s of 14.5 nM and 6.2 nM, respectively. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells. References: Cancer Res. 2012 Oct 1; 72(19):5025-34; Medchemcomm. 2012 Jun 1; 3(6):699-709.
Molecular Weight (MW)	326.37
Formula	C16H14N4O2S
CAS No.	1342278-01-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 65 mg/mL (199.16 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	15% Captisol: 15 mg/mL
Synonyms	RKI 1447; ROCK Inhibitor XIII; RKI-1447; RKI1447;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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