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LDN-193189 4HCl

LDN-193189 4HCl

Item no.	V1372-250mg
Manufacturer	InvivoChem LLC
CASRN	1062368-62-0
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1372CAS #:1062368-62-0Purity >=98% Description: LDN193189 4HCl (LDN-193189; DM-3189; LDN 193189; DM 3189), the tetrahydrochloride salt of LDN193189, is a highly potent and selective inhibitor of the BMP (bone morphogenetic protein) signaling pathway with potential anticancer activity. LDN-193189 also exhibits inhibitory effects on associated vascular inflammation, osteogenic activity, and calcification. It inhibits the transcriptional activity of the BMP type I receptor kinases such as ALK2 (activin receptor-like kinase-2) and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells, respectively. LDN-193189 also exhibits inhibitory effects on associated vascular inflammation, osteogenic activity, and calcification. References: Nat Med. 2008 Dec; 14(12):1363-9; Br J Pharmacol. 2010 Sep; 161(1):140-9. Related CAS #: 1062368-24-4 (free base) 2310134-98-4 or 1062368-62-0 (4HCl) 1435934-00-1 (dihydrochloride) #: 1062368-24-4 (free base) 1435934-00-1 (dihydrochloride)
Molecular Weight (MW)	552.33
Formula	C??H??Cl?N?
CAS No.	1062368-62-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 20 mg/mL
	Water: > 20 mg/mL
	Ethanol:
SMILES Code	C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16.Cl.Cl.Cl.Cl
Synonyms	DM3189 4HCl; LDN193189 4HCl; DM-3189 4HCl; LDN 193189 4HCl; DM 3189 4HCl; LDN-193189 4HCl

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Amount: 250 mg

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