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Betulinic acid (ALS357; Lupatic acid)

Betulinic acid (ALS357; Lupatic acid)

Item no.	V1401-500mg
Manufacturer	InvivoChem LLC
CASRN	472-15-1
Amount	500 mg
Quantity options	100 mg 1 g 250 mg 2 g 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1401CAS #:472-15-1Purity >=98% Description: Betulinic acid (also known as ALS-357; LS-357; Mairin; Lupatic acid; Betulic acid) is a naturally occuring pentacyclic triterpenoid extracted from Syzigium claviflorum that displays anti-HIV and antitumor activity. Betulinic acid acts as an inhibitor of HIV-1 with an EC50 of 1.4 u M. Betulinic acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic acid also displays TGR5 agonist activity (EC50 =1.04 uM). Description: References: Planta Med. 1998 Oct; 64(7):655-7; J Nat Prod. 1994 Feb; 57(2):243-7. References:
Molecular Weight (MW)	456.7
Formula	C30H48O3
CAS No.	472-15-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (43.8 mM)
	Water: < 1 mg/mL
	Ethanol: 10 mg/mL (21.9 mM)
Solubility (In vivo)	Chemical Name: (1R, 3aS, 5aR, 5bR, 7aR, 9S, 11aR, 11bR, 13aR, 13bR)-9-hydroxy-5a, 5b, 8, 8, 11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid InChi Key: QGJZLNKBHJESQX-FZFNOLFKSA-N InChi Code: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3, 4)21(27)11-14-29(22, 28)7/h19-24, 31H, 1, 8-17H2, 2-7H3, (H, 32, 33)/t19-, 20+, 21-, 22+, 23-, 24+, 27-, 28+, 29+, 30-/m0/s1 SMILES Code: O=C([C]1(CC[CH]2C(C)=C)[C]2([H])[C]3([H])CC[C]4([H])[C]5(C)CC[CH](O)C(C)(C)[C]5([H])CC[C]4(C)[C]3(C)CC1)O
Synonyms	Lupatic acid; ALS357; ALS 357; Betulic acid; ALS-357; Mairin.

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Amount: 500 mg

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