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Mitomycin C (Ametycine)

Mitomycin C (Ametycine)

Item no.	V1426-1g
Manufacturer	InvivoChem LLC
CASRN	50-07-7
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1426CAS #:50-07-7Purity >=98% Description: Mitomycin C (Mitozytrex; Mutamycin; Ametycine) is an antineoplastic antibiotic drug that acts by inhibiting DNA synthesis, and has been approved to treat different cancers. Mitomycine C is a methylazirinopyrroloindoledione analog isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Description: References: Mol Cell. 2009 Sep 11; 35(5):704-15; Cell Cycle. 2012 Sep 1; 11(17):3312-23. References
Molecular Weight (MW)	334.37
Formula	C15H18N4O5
CAS No.	50-07-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (200.4 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	Chemical Name: ((1aS, 8S, 8aR, 8bS)-6-amino-8a-methoxy-5-methyl-4, 7-dioxo-1, 1a, 2, 4, 7, 8, 8a, 8b-octahydroazirino[2', 3':3, 4]pyrrolo[1, 2-a]indol-8-yl)methyl carbamate InChi Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N InChi Code: NC(OCC[4:S=I]H()C[5:S=N]()(OC)C[6:S=N]()(H)NC[S=N](CN6C[16]()=C5C(C(N)=C(C16=O)C)=O)7-H)=O SMILES Code: NC(OC[CH]1[C]([C](N2)([H])[C]2([H])C3)(OC)N3C4=C1C(C(N)=C(C)C4=O)=O)=O
Synonyms	Ametycine; mitomycine C; mitomycinX. US trade names: Mitozytrex; Mutamycin. Foreign brand names: Ametycine; MitocinC; Mitolem; MitoMedac; Mutamycine. Abbreviations: MITC; MITO; MITOC; MTC; NCIC04706

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