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Clevudine (L-FMAU)

Clevudine (L-FMAU)

Item no.	V1467-100mg
Manufacturer	InvivoChem LLC
CASRN	163252-36-6
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1467CAS #:163252-36-6 Purity >=98% Description: Clevudine (L-FMAU; L FMAU; Levovir and Revovir) is a potent antiviral drug approved in South Korea and the Philippines for the treatment of hepatitis B (HBV) infections with EC50 0.1 uM in HepG2 2.2.15 cells as well as EBV. Clevudine has low cytotoxicities in a variety of cell lines including MT2, CEM, H1 and HepG2 2.2.15 and bone marrow progenitor cells. Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate. Description: References: Bioorg Med Chem Lett. 2002 Dec 2; 12(23):3459-62; Antimicrob Agents Chemother. 2005 May; 49(5):2044-9. References: Related CAS#: 174625-00-4 (Clevudine triphosphate); 163252-36-6 (free base)
Molecular Weight (MW)	260.22
Formula	C10H13FN2O5
CAS No.	163252-36-6 (Clevudine);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 52 mg/mL (199.8 mM)
	Water: 52 mg/mL (199.8 mM) < 1 mg/mL
	Ethanol: 4 mg/mL (15.4 mM)
Other info	Chemical Name: 1-((2S, 3R, 4S, 5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2, 4(1H, 3H)-dione InChi Key: GBBJCSTXCAQSSJ-XQXXSGGOSA-N InChi Code: InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2, 5-7, 9, 14-15H, 3H2, 1H3, (H, 12, 16, 17)/t5-, 6+, 7-, 9-/m0/s1 SMILES Code: O=C1NC(C(C)=CN1[CH]2[CH](F)[CH]([CH](CO)O2)O)=O
Synonyms	L-FMAU; L FMAU; LFMAU

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 100 mg

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Delivery expected until 9/4/2025

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