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Istradefylline (KW-6002)

Istradefylline (KW-6002)

Item no.	V1483-500mg
Manufacturer	InvivoChem LLC
CASRN	155270-99-8
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1483CAS #:155270-99-8Purity >=98% Description: Istradefylline (formerly KW6002; KW 6002; KW-6002; Nourianz), a caffeine derivative, is an orally bioavailable and selective adenosine A2A receptor (A2AR) antagonist with anti-PD (Parkinson's disease) effects. It inhibits A2A receptor (A2AR) with a Ki of 2.2 nM. It has been approved to be used as an add-on treatment to levodopa/carbidopa for patients with Parkinson's disease experiencing 'off' episodes. Istradefylline reduces 'off' periods resulting from long-term treatment with the antiparkinson drug levodopa. Description: References: J Neurosci. 2001 May 15; 21(10):RC143; Psychopharmacology (Berl). 1999 Nov; 147(1):90-5. References: Related CAS: 160434-48-0 (4-Desmethyl Istradefylline)
Molecular Weight (MW)	384.43
Formula	C20H24N4O4
CAS No.	155270-99-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 6 mg/mL (15.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	KW-6002; KW6002; KW 6002;

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Amount: 500 mg

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