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Description: NPS-2143 (also called SB262470; NPS-2143; SB-262470; NPS 2143; SB-262470A) is a potent and selective antagonist of calcium-sensing receptor (CaSR) with the potential to be used for the treatment of osteoporosis. It inhibits CaSR with an IC50 of 43 nM.
References: J Pharmacol Exp Ther. 2001 Oct; 299(1):323-31; J Endocrinol. 2006 Oct; 191(1):189-95.
Related CAS#: 284035-33-2 (free base); 324523-20-8 (HCl).
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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