SKI II

Item no.	V1503-50mg
Manufacturer	InvivoChem LLC
CASRN	312636-16-1
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1503CAS #:312636-16-1Purity >=98% Description: SKI II (also known as SphK-I2) is a potent, highly selective, non-lipid and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 uM, while it exhibits no inhibitory effects on other kinases including PI3K, PKCalpha and ERK2. SKI-II inhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells. Description: References: Cancer Res. 2003 Sep 15; 63(18):5962-9; J Pharmacol Exp Ther. 2006 Aug; 318(2):596-603. References:
Molecular Weight (MW)	302.78
Formula	C15H11ClN2OS
CAS No.	312636-16-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 61 mg/mL (201.5 mM)
	Water: < 1 mg/mL
	Ethanol: 61 mg/mL (201.5 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 20 mg/mL
Synonyms	SphK-I2; SKI-II; SKIII; SKI II. Sphingosine kinase inhibitor II

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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