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Bosentan Hydrate (Ro 47-0203)

Bosentan Hydrate (Ro 47-0203)

Item no.	V1509-5g
Manufacturer	InvivoChem LLC
CASRN	157212-55-0
Amount	5 g
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1509CAS #:157212-55-0Purity >=98% Description: Bosentan Hydrate (also known as Ro 47-0203 Hydrate) is a potent, competitive and dual endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Bosentan is used as a vasodilator. Bosentan is an inhibitor of ETAR and ETBR. It is used for the treatment of pulmonary artery hypertension (PAH). Bosentan blocks the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. Description: References: Pathophysiology. 2003 Sep; 9(4):249-256; J Pharmacol Exp Ther. 1994 Jul; 270(1):228-35. References: Related CAS #:147536-97-8 (free) 157212-55-0 (Bosentan hydrate) 253688-60-7 Hydroxy bosentan (Ro 48-5033) 253688-62-9 Hydroxy desmethyl Bosentan (Ro 64-105)
Molecular Weight (MW)	569.63
Formula	C27H29N5O6S.H2O
CAS No.	157212-55-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (175.6 mM)
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL (3.5 mM)
Other info	Chemical Name: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide hydrate SMILES Code: O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=CC=CC=C3OC)(C4=CC=C(C(C)(C)C)C=C4)=O.O
Synonyms	Ro-47-0203; Ro 47-0203; Ro47-0203; bosentan anhydrous; bosentan monohydrate; Ro47 0203; Ro-47 0203; Tracleer

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Amount: 5 g

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