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Sitaxentan sodium (Sitaxsentan; IPI 1040)

Sitaxentan sodium (Sitaxsentan; IPI 1040)

Item no.	V1511-250mg
Manufacturer	InvivoChem LLC
CASRN	210421-74-2
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1511CAS #:210421-74-2Purity >=98% Description: Sitaxentan sodium (also known as Sitaxsentan, TBC-11251 and IPI 1040) is a selective and orally bioavailable endothelin A receptor (ETA) antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively, it exhibits 7000-fold selectivity over ETB. Sitaxentanis a medication for the treatment of pulmonary arterial hypertension (PAH). Sitaxentan is a small molecule that blocks the action of endothelin (ET) on the endothelin-A (ETA) receptor selectively (by a factor of 6000 compared with the ETB). Description: References: J Med Chem. 1997; 40(11):1690-7; Pulm Pharmacol Ther. 2000; 13(2):87-97; Neurosurgery. 1998; 43(6):1409-17. References: Related CAS: 210421-74-2 (sodium salt); 184036-34-8 (free)
Molecular Weight (MW)	476.89
Formula	C18H14ClN2O6S2.Na
CAS No.	210421-74-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (83.9 mM)
	Water: < 1 mg/mL
	Ethanol: 20 mg/mL (41.9 mM)
Solubility (In vivo)	Name: sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1, 3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide InChi Key: MDTNUYUCUYPIHE-UHFFFAOYSA-N InChi Code: InChI=1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23, 24)21-18-16(19)10(2)20-27-18; /h3-5, 7H, 6, 8H2, 1-2H3; /q-1; +1 SMILES Code: O=C(C(SC=C1)=C1S(N([Na])C2=C(C(C)=NO2)Cl)(=O)=O)CC3=C(C)C=C(OCO4)C4=C3
Synonyms	IPI-1040; IPI1040; IPI 1040; TBC-11251; TBC11251; TBC 11251; TBC-11251 sodium salt, Sitaxsentan; Thelin; Sitaxentan sodium

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Amount: 250 mg

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Delivery expected until 9/4/2025

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