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Ambrisentan (BSF 208075; LU 208075)

Ambrisentan (BSF 208075; LU 208075)

Item no.	V1512-2g
Manufacturer	InvivoChem LLC
CASRN	177036-94-1
Amount	2 g
Quantity options	100 mg 1 g 250 mg 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1512CAS #:177036-94-1Purity >=98% Description: Ambrisentan (formerly also known as BSF-208075 and LU-208075) is a novel, potent and highly selective antagonist of the endothelin-1 type A receptor. Ambrisentanis a drug used for the treatment of pulmonary hypertension. Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension. Description: References: Biol Pharm Bull. 2014; 37(3):461-5; Biochem Pharmacol. 2013 Jan 15; 85(2):265-73. References:
Molecular Weight (MW)	378.42
Formula	C22H22N2O4
CAS No.	177036-94-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 76 mg/mL (200.8 mM)
	Water: < 1 mg/mL
	Ethanol: 22 mg/mL (58.1 mM)
Other info	IUPAC/Chemical Name: (S)-2-((4, 6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3, 3-diphenylpropanoic acid InChi Key: OUJTZYPIHDYQMC-LJQANCHMSA-N InChi Code: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3, 17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14, 19H, 1-3H3, (H, 25, 26)/t19-/m1/s1 SMILES Code: O=C(O)[CH](OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3
Synonyms	LU-208075, BSF-208075; BSF208075; LU208075; BSF 208075; LU 208075; trade name Letairis; Volibris; pulmonext.

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Amount: 2 g

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