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Description: SPI-112, the SPI-112 methyl ester analogue was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
References: Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Biochem Pharmacol. 2010 Sep 15; 80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25.PMID: 20510203 Free PMC ArticleSimilar articles
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