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Bisindolylmaleimide I (GF109203X)

Bisindolylmaleimide I (GF109203X)

Item no.	V1526-25mg
Manufacturer	InvivoChem LLC
CASRN	133052-90-1
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1526CAS #:133052-90-1Purity >=98% Description: GF109203X (also known as GF109203 X; bisindolylmaleimide; Go 6850) is a novel, potent, highly selective, cell-permeable, and reversible PKC (protein kinase C) inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCalpha, PKCbetaI, PKCbetaII, and PKCgamma in cell-free assays, respectively, it showed more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates IC50 360 nM or in GSK-3beta immunoprecipitates IC50 170 nM derived from rat epididymal adipocytes. References: J Biol Chem. 1991; 266(24):15771-81; Br J Cancer. 1996; 74(6):897-905; Br J Pharmacol. 2002; 135(1):239-47.
Molecular Weight (MW)	412.48
Formula	C25H24N4O2
CAS No.	133052-90-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 82 mg/mL (198.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2, 5-dione InChi Key: QMGUOJYZJKLOLH-UHFFFAOYSA-N InChi Code: InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6, 8-11, 14-15, 26H, 7, 12-13H2, 1-2H3, (H, 27, 30, 31) SMILES Code: O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O
Synonyms	GO 6850 , Bisindolylmaleimide I; GF109203X; GF-109203 X; GF-109203X; GF 109203X; bisindolylmaleimide; GO 6850; GO-6850; GO6850. BIMI.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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