Comparison

Ro 31-8220 Mesylate

Item no. V1528-500mg
Manufacturer InvivoChem LLC
CASRN 138489-18-6
Amount 500 mg
Quantity options 100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V1528CAS #:138489-18-6 Purity >=98%

Description: Ro 31-8220 mesylate is a novel and potent pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3beta and S6K1. Ro-31-8220 displayed apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol.

References: Biochem J. 1993; 294 ( Pt 2):335-7; Br J Cancer. 1995 Apr; 71(4):697-704; Circulation. 2006; 114(6):574-82.

Related CAS#:125314-64-9 (free base); 138489-18-6 (mesylate)

Molecular Weight (MW)
553.65
Formula
C25H23N5O2S.CH4O3S
CAS No.
138489-18-6 (mesylate);
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (180.6 mM)
Water: < 1 mg/mL
Ethanol: < 1 mg/mL
Solubility (In vivo)
NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
Synonyms
Bisindolylmaleimide IX Mesylate; BIM IX; RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 mg
Available: In stock
available

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