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Dequalinium Chloride

Dequalinium Chloride

Item no.	V1529-1g
Manufacturer	InvivoChem LLC
CASRN	522-51-0
Amount	1 g
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1529CAS #:522-51-0Purity >=98% Description: Dequalinium Chloride is a potent PKC inhibitor with IC50 of 7-18 uM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 uM. Dequalinium is selectively accumulated and retained within the mitochondria of carcinoma cells where it blocked mitochondrial enzymes which can then disrupt cellular energy production, eventually resulting in cell death. Dequalinium is a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle. References: Gynecol Oncol. 1993; 50:38-44; Eur J Pharmacol. 1993; 236:201-7; Proc Natl Acad Sci U S A. 1987; 84:5444-8.
Molecular Weight (MW)	527.57
Formula	C30H40N4.2Cl
CAS No.	522-51-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: < 1 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 1, 1'-(decane-1, 10-diyl)bis(4-amino-2-methylquinolin-1-ium) chloride InChi Key: LTNZEXKYNRNOGT-UHFFFAOYSA-N InChi Code: InChI=1S/C30H38N4.2ClH/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34; ; /h9-12, 15-18, 21-22, 31-32H, 3-8, 13-14, 19-20H2, 1-2H3; 2*1H SMILES Code: CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C.[Cl-].[Cl-]
Synonyms	Dequavagyn; NSC 166454; NSC-166454; NSC166454

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