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K03861 (AUZ 454)

K03861 (AUZ 454)

Item no.	V1536-100mg
Manufacturer	InvivoChem LLC
CASRN	853299-07-7
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1536CAS #:853299-07-7Purity >=98% Description: K03861 is an aminopyrimidine-phenyl urea and a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. The cocrystal structure of CDK2 with the inhibitor K03861 revealed a canonical type II binding mode. K03861 competes with the binding of cyclins. The residues important for the type II inhibitors may be distant to the ATP binding pockets. The crystal structure of this complex may provide a foundation for the cyclin-competitive CDK2 inhibitors References: ACS Chem Biol. 2015 Sep 18; 10(9):2116-25.
Molecular Weight (MW)	501.50
Formula	C24H26F3N7O2
CAS No.	853299-07-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.4 mM)
	Water: < 1 mg/mL
	Ethanol: 15 mg/mL (29.9 mM)
Other info	Chemical Name: 1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea InChi Key: PWDLXPJQFNVTNL-UHFFFAOYSA-N InChi Code: InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25, 26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9, 14H, 10-13, 15H2, 1H3, (H2, 28, 29, 32)(H2, 30, 31, 35) SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3
Synonyms	K03861; K-03861; K 03861; AUZ454; AUZ 454; AUZ-454

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Amount: 100 mg

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