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Description: SU-4312, formerly known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 are 0.8 and 19.4 uM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
References: Li Y, Zhu H, Klausen C, Peng B, Leung PC. Vascular Endothelial Growth Factor-A(VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like TubeFormation. Endocrinology. 2015 Nov; 156(11):4257-68. doi: 10.1210/en.2015-1228.PubMed PMID: 26327470.
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