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XL413 (BMS-863233) HCl

XL413 (BMS-863233) HCl

Item no.	V1543-500mg
Manufacturer	InvivoChem LLC
CASRN	1169562-71-3
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1543CAS #:1169562-71-3Purity >=98% Description: XL413 HCl (BMS-863233) is a novel, highly potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, it shows 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. In MDA-MB-231T and Colo-205 cell lines, XL413 results in inhibition of CDC7 specific phosphorylation of MCM2. XL413 also inhibits the cell proliferation, decreases cell viability and elicits the caspase 3/7 activity in Colo-205 cells. Moreover, XL413 results in modified S phase progression that subsequently leads to apoptotic cell death. References: Bioorg Med Chem Lett. 2012 Jun 1; 22(11):3727-31. Related CAS #: 1169562-71-3 (HCl) 1169558-38-6 (free base)
Molecular Weight (MW)	326.18
Formula	C14H13Cl2N3O2
CAS No.	1169562-71-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: < 1 mg/mL
	Water: 46 mg/mL (141.02 mM)
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3, 2-d]pyrimidin-4(3H)-one hydrochloride InChi Key: UNDKJUKLBNARIZ-FVGYRXGTSA-N InChi Code: InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9; /h3-4, 6, 9, 16H, 1-2, 5H2, (H, 17, 18, 19); 1H/t9-; /m0./s1 SMILES Code: O=C1C(OC2=CC=C(Cl)C=C23)=C3N=C([CH]4NCCC4)N1.[H]Cl
Synonyms	XL413; XL-413; XL 413; BMS863233; BMS-863233; BMS 863233.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 500 mg

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Delivery expected until 10/2/2025

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