BS-181 HCl

Description: BS-181 HCl is a novel, highly selective, and small molecule CDK7 inhibitor with IC50 of 21 NM in a cell-free assay. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Among the CDKs and other 69 kinases from many different classes, BS-181 shows high inhibitory selectivity for CDK7, inhibits CDK2 at concentrations lower than 1 uM which being inhibited 35-fold less potently (IC50 with 880 nM) than CDK7, shows slight inhibition for CDK1, CDK4, CDK5, CDK6 and CDK9 with IC50 values higher than 3.0 uM, and only shows inhibition for several kinases from other classes at high concentrations (> 10 uM).

References: Cancer Res. 2009 Aug 1; 69(15):6208-15.

Related CAS#: 1092443-52-1 (free base); 1397219-81-6 (HCl); 1883548-83-1 (2HCl)