ZCL278

Item no.	V1564-500mg
Manufacturer	InvivoChem LLC
CASRN	587841-73-4
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1564CAS #:587841-73-4Purity >=98% Description: ZCL278 is a potent, cell-permeable and selective Cdc42 GTPase inhibitor with Kd of 11.4 uM. In human metastatic prostate cancer PC-3 cells, ZCL278 showed inhibitory function on Rac/Cdc42 phosphorylation and the function increasing as the more-treated time. In cortical neurons, ZCL278 treatment suppressed neuronal branch number and inhibited growth cone motility. Treated serum-starved Swiss 3T3 fibroblasts Cdc42 activator following administration of ZCL278 at the dose of 50 uM for 1 h exhibited a significant decrease (nearly 80%) in GTP-Cdc42 and disrupted perinuclear distribution of active Cdc42. References: Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1261-6.
Molecular Weight (MW)	584.89
Formula	C21H19BrClN5O4S2
CAS No.	587841-73-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (170.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4, 6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide InChi Key: XKZDWYDHEBCGCG-UHFFFAOYSA-N InChi Code: InChI=1S/C21H19BrClN5O4S2/c1-12-9-13(2)25-20(24-12)28-34(30, 31)16-6-4-15(5-7-16)26-21(33)27-19(29)11-32-18-8-3-14(22)10-17(18)23/h3-10H, 11H2, 1-2H3, (H, 24, 25, 28)(H2, 26, 27, 29, 33) SMILES Code: O=C(NC(NC1=CC=C(S(=O)(NC2=NC(C)=CC(C)=N2)=O)C=C1)=S)COC3=CC=C(Br)C=C3Cl
Synonyms	ZCL-278; ZCL 278; ZCL278.

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Amount: 500 mg

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