« Back
Home /
Salirasib (Farnesyl Thiosalicylic Acid)

Salirasib (Farnesyl Thiosalicylic Acid)

Item no.	V1568-250mg
Manufacturer	InvivoChem LLC
CASRN	162520-00-5
Amount	250 mg
Quantity options	100 mg 10 mg 1 g 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1568CAS #:162520-00-5Purity >=98% Description: Salirasib (known also as S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 uM, which inhibits Ras methylation. Salirasib is a salicylic acid analog with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. References: J Med Chem. 1995; 38(8):1267-72; J Biol Chem. 1995; 270(38):22263-70; Oncogene. 1999; 18(16):2579-88.
Molecular Weight (MW)	358.54
Formula	C22H30O2S
CAS No.	162520-00-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2-(((2E, 6E)-3, 7, 11-trimethyldodeca-2, 6, 10-trien-1-yl)thio)benzoic acid InChi Key: WUILNKCFCLNXOK-CFBAGHHKSA-N InChi Code: InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6, 9, 11, 13-15H, 7-8, 10, 12, 16H2, 1-4H3, (H, 23, 24)/b18-11+, 19-15+ SMILES Code: O=C(O)C1=CC=CC=C1SC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C
Synonyms	Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer