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K-Ras inhibitor 12

K-Ras inhibitor 12

Item no.	V1570-250mg
Manufacturer	InvivoChem LLC
CASRN	1469337-95-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1570CAS #:1469337-95-8Purity >=98% Description: K-Ras(G12C) inhibitor 12 is a potent, selective and allosteric inhibitor of oncogenic K-Ras(G12C), the mutated form of K-ras. It binds to K-Ras(G12C) by forming a covalent bond with the 12C cysteine. K-Ras(G12C) exhibited a slight preference for GTP. However, K-Ras(G12C) inhibitor 12 significantly reduced the affinity for GTP and led to the modification of K-Ras(G12C). Also, K-Ras(G12C) inhibitor 12 inhibited SOS-catalysed nucleotide exchange. In H1792 and H358 K-Ras(G12C)-mutant lung cancer cell lines, K-Ras(G12C) inhibitor 12 reduced the association of C-Raf and B-Raf with Ras. References: Nature. 2013 Nov 28; 503(7477):548-51.
Molecular Weight (MW)	449.67
Formula	C15H17ClIN3O3
CAS No.	1469337-95-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 27 mg/mL (60.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one InChi Key: JFIFBWVNHLXJFY-UHFFFAOYSA-N InChi Code: InChI=1S/C15H17ClIN3O3/c1-2-14(22)19-3-5-20(6-4-19)15(23)9-18-12-8-11(17)10(16)7-13(12)21/h2, 7-8, 18, 21H, 1, 3-6, 9H2 SMILES Code: C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
Synonyms	K-Ras(G12C) inhibitor 12; K-Ras(G12C) inhibitor

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Amount: 250 mg

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Delivery expected until 9/4/2025

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