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AZD7762

AZD7762

Item no.	V1582-250mg
Manufacturer	InvivoChem LLC
CASRN	860352-01-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1582CAS #:860352-01-8 (free base)Purity >=98% Description: AZD7762 is a novel, potent, selective and ATP-competitive small molecule inhibitor of Chk1 (checkpoint kinases) with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. AZD7762 prevents cell cycle arrest and DNA repair in DNA damaged tumor cells, causing tumor cell apoptosis. Hence, it potentiates the antitumor activity of DNA damaging agents and can be used as a chemosensitizing agent. Chk1 (checkpoint kinases) are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication. References: Mol Cancer Ther. 2008 Sep; 7(9):2955-66. Related CAS?1246094-78-9 (AZD7762 HCl); 860352-01-8 (free base)
Molecular Weight (MW)	362.42
Formula	C17H19FN4O2S
CAS No.	860352-01-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 50 mg/mL (138.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide InChi Key: IAYGCINLNONXHY-LBPRGKRZSA-N InChi Code: InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1, 3-4, 7-8, 12, 20H, 2, 5-6, 9H2, (H, 21, 23)(H3, 19, 22, 24)/t12-/m0/s1 SMILES Code: O=C(C1=C(NC(N)=O)C=C(C2=CC=CC(F)=C2)S1)N[CH]3CNCCC3
Synonyms	AZD7762; AZD 7762; AZD-7762

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Amount: 250 mg

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Delivery expected until 9/4/2025

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