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Combretastatin A4 (CA-4; CRC 87-09)

Combretastatin A4 (CA-4; CRC 87-09)

Item no.	V1610-500mg
Manufacturer	InvivoChem LLC
CASRN	117048-59-6
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1610CAS #:117048-59-6Purity >=98% Description: Combretastatin A4 (CA-4; CRC-87-09) is a highly potent tubulin inhibitor with potential antitumor activity. It belongs to the so called microtubule-targeting agent (MTA) or microtubule disrupting agent and acts by binding to beta-tubulin with a Kd of 0.4 uM. References: J Med Chem. 2014 Apr 24; 57(8):3369-81; Magn Reson Med. 2016 Feb; 75(2):866-72. Publications Citing Use of InvivoChem Combretastatin A4 (CA-4; CRC 87-09): 1) Eur J Med Chem. 2019 Dec 15; 184:111732. doi: 10.1016/j.ejmech.2019.111732; 2) Eur J Med Chem. 2021 Mar 5; 213:113058. doi: 10.1016/j.ejmech.2020.113058.
Molecular Weight (MW)	316.35
Formula	C18H20O5
CAS No.	117048-59-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (199.1 mM)
	Water:< 1 mg/mL
	Ethanol: 34 mg/mL (107.5 mM)
Solubility (In vivo)	5% DMSO+50% PEG 300+ddH2O: 30mg/mL
Synonyms	Combretastatin A-4; Combretastatin A 4; Combretastatin A4; CRC 87-09; CRC 87-09; CRC 87-09; CA-4; CA4; CA 4;

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