CW069

Item no.	V1618-10mg
Manufacturer	InvivoChem LLC
CASRN	1594094-64-0
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1618CAS #:1594094-64-0 Purity >=98% Description: CW069 is a potent, selective and allosteric inhibitor of microtubule motor protein HSET with IC50 of 75 uM. CW069 exhibited significant selectivity over KSP. In silico model for HSET binding, the highly favorable hydrogen bond formed between the carboxylate of CW069 and the guanidinium group of Arg521 in HSET. Also, a cation-piinteraction formed between the exposed phenyl group of CW069 and the Arg521 side chain. Arg521 was critical for CW069 selectivity. References: Chem Biol. 2013 Nov 21; 20(11):1399-410.
Molecular Weight (MW)	500.33
Formula	C23H21IN2O3
CAS No.	1594094-64-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.9 mM)
	Water: < 1 mg/mL
	Ethanol: 4 mg/mL (8.0 mM)
Other info	Chemical Name: 5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-benzoic acid InChi Key: IRDIXDXDSUBHIU-NRFANRHFSA-N InChi Code: InChI=1S/C23H21IN2O3/c24-18-11-12-20(19(14-18)23(28)29)26-22(27)21(13-16-7-3-1-4-8-16)25-15-17-9-5-2-6-10-17/h1-12, 14, 21, 25H, 13, 15H2, (H, 26, 27)(H, 28, 29)/t21-/m0/s1 SMILES Code: O=C(O)C1=CC(I)=CC=C1NC([CH](NCC2=CC=CC=C2)CC3=CC=CC=C3)=O
Synonyms	CW069; CW-069; CW 069

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Amount: 10 mg

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