gsk923295

Description: GSK923295 (also known as GSK-923295A) is a novel, potent, first-in-class, specific and allosteric inhibitor of CENP-E (centromere-associated protein E) kinesin motor ATPase with Ki of 3.2 nM, and it is less potent to mutant I182 and T183. GSK-923295 is an antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK923295A demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts.

References: Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5839-44; Pediatr Blood Cancer. 2012 Jun; 58(6):916-23.