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ARQ 621

ARQ 621

Item no.	V1631-25mg
Manufacturer	InvivoChem LLC
CASRN	1095253-39-6
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1631CAS #:1095253-39-6Purity >=98% Description: ARQ 621 is a potent, allosteric, and selective Eg5 mitotic motor protein inhibitor. Eg5 is essential for the dynamic organization of the mitotic spindle. Over-expression of Eg5 leads to genomic instability and tumor formation. Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies. References: Rosen L, et al. Annual Meeting of ASCO: abstract 3076
Molecular Weight (MW)	552.43
Formula	C28H24Cl2FN5O2
CAS No.	1095253-39-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (181.0 mM)
	Water:< 1 mg/mL
	Ethanol: 100 mg/mL (181.0 mM)
Other info	Chemical Name: (R)-N-(3-aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3, 4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide InChi Key: UPJSUQWHUVLLNW-XMMPIXPASA-N InChi Code: InChI=1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1, 3-6, 9-14, 17, 24, 34H, 7-8, 15-16, 32H2/t24-/m1/s1 SMILES Code: O=C(N(CCCN)[CH](C(N1NC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC#C)C4=CC=CC(Cl)=C4F
Synonyms	ARQ621; ARQ 621; ARQ-621

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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