Propafenone HCl (SA-79)

Description: Propafenone HCl (SA-79) is a class 1C anti-arrhythmic medication and a sodium channel protein inhibitor, which is used to treat illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias. Propafenone works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells. Propafenone is more selective for cells with a high rate, but also blocks normal cells more than class Ia or Ib. Propafenone differs from the prototypical class Ic antiarrhythmic in that it has additional activity as a beta-adrenergic blocker which can cause bradycardia and bronchospasm.

References: Eur J Clin Pharmacol. 1983; 25(6):831-3; Experientia. 1980 Sep 15; 36(9):1082-3.

Propafenone HCl; Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain;