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Triamterene (SKF8542)

Triamterene (SKF8542)

Item no.	V1668-10g
Manufacturer	InvivoChem LLC
CASRN	396-01-0
Amount	10 g
Quantity options	1 g 250 mg 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V1668CAS #:396-01-0 Purity >=98% Description: Triamterene (also known as SKF8542) is a weak diuretic with potassium sparing properties. It blocks Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 uM. Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubule, which are responsible for 1-2% of total sodium reabsorption. Triamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitium. References: Mol Pharmacol. 2003 Oct; 64(4):848-56; Int J Clin Pharmacol Ther. 2005 Jul; 43(7):327-34.
Molecular Weight (MW)	253.26
Formula	C12H11N7
CAS No.	396-01-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (79 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	0.5% CMC Na+1% Tween 80: 30 mg/mL
Synonyms	SKF-8542; SKF 8542; SKF8542; BRN 0266723; BRN0266723; BRN-0266723; Triamterene; Diucelpin; Diurene

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Amount: 10 g

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Delivery expected until 9/4/2025

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