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Lumacaftor (VX-809; VRT 826809)

Lumacaftor (VX-809; VRT 826809)

Item no.	V1690-1g
Manufacturer	InvivoChem LLC
CASRN	936727-05-8
Amount	1 g
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1690CAS #:936727-05-8Purity >=98% Description: Lumacaftor (also known as VX-809 or VRT 826809) is a potent and orally active CFTR corrector that acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation, with EC50 of 0.1 uM in fisher rat thyroid cells. VX-809 may be useful for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation. Cystic fibrosis (CF) is a genetic disorder that causes multiorgan morbidity and premature death, most commonly from pulmonary dysfunction. References: Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18843-8.
Molecular Weight (MW)	452.41
Formula	C24H18F2N2O5
CAS No.	936727-05-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (198.9 mM)
	Water: < 1 mg/mL
	Ethanol: 6 mg/mL (13.3 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
Synonyms	VRT-826809; VRT 826809; VRT826809; VX-809; VX809; VX 809; Lumacaftor; Orkambi

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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