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IOWH032

IOWH032

Item no.	V1694-1g
Manufacturer	InvivoChem LLC
CASRN	1191252-49-9
Amount	1 g
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1694CAS #:1191252-49-9Purity >=98% Description: IOWH-032 is a potent and synthetic CFTR inhibitor with IC50 of 1.01 uM in CHO-CFTR cell based assays. IOWH032 inhibited CFTR activity with IC50 value of 6.87 uM in T84-CFTR cell based assays 1. IOWH-032 rapidly blocked and potentiated hCFTR activity in a concentration-dependent manner with apparent Kd value of 6.1 nM and 0.64 nM, respectively. However, IOWH-032 did not potentiate and only blocked mCFTR with an apparent Kd value of 42.9 uM. References: Future Med Chem. 2011 Aug; 3(10):1317-25.
Molecular Weight (MW)	545.18
Formula	C22H15Br2N3O4
CAS No.	1191252-49-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (183.4 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 3-(3, 5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1, 2, 4-oxadiazole-5-carboxamide . InChi Key: DSFNLJXHXBIKDS-UHFFFAOYSA-N InChi Code: InChI=1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11, 28H, 12H2, (H, 25, 29) SMILES Code: O=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3
Synonyms	IOWH032; IOWH-032; IOWH 032

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