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Description: Prednisolone is a potent and synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats.
References: Proc Soc Exp Biol Med. 1994 Mar; 205(3):220-9; J Clin Invest. 1993 Sep; 92(3):1534-42.
Related CAS #: 50-24-8 (free) 52-21-1 (acetate) 125-02-0 (Na+ phosphate)
Chemical Name: (8S, 9S, 10R, 11S, 13S, 14S, 17R)-11, 17-Dihydroxy-17-(2-hydroxyacetyl)-10, 13-dimethyl-7, 8, 9, 11, 12, 14, 15, 16-octahydro-6H-cyclopenta[a]phenanthren-3-one
InChi Key: OIGNJSKKLXVSLS-VWUMJDOOSA-N
InChi Code: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26, 17(25)11-22)20(15, 2)10-16(24)18(14)19/h5, 7, 9, 14-16, 18, 22, 24, 26H, 3-4, 6, 8, 10-11H2, 1-2H3/t14-, 15-, 16-, 18+, 19-, 20-, 21-/m0/s1
SMILES Code: O=C1C=C[C]2(C)[C]3([H])[CH](O)C[C]4(C)[C](C(CO)=O)(O)CC[C]4([H])[C]3([H])CCC2=C1
AKOS016010152; AK115681; sodium phosphate Predsol; Pediapred
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