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Description: Meprednisone, also known as NSC 527579, SCH 4358, NSC-63278 and Betapar, is a glucocorticoid and a methylated derivative of prednisone. Meprednisone is a glucocorticoid receptor agonist used to treat allergic and inflammatory of the eye. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats due to altered interconversion between these steroids.
References: Am J Contact Dermat. 2003 Dec; 14(4):179-87.
Chemical Name: (8S, 9S, 10R, 13S, 14S, 16S, 17R)-17-hydroxy-17-(2-hydroxyacetyl)-10, 13, 16-trimethyl-7, 8, 9, 10, 12, 13, 14, 15, 16, 17-decahydro-3H-cyclopenta[a]phenanthrene-3, 11(6H)-dione
InChi Key: PIDANAQULIKBQS-RNUIGHNZSA-N
InChi Code: InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13, 2)19(15)17(25)10-21(16, 3)22(12, 27)18(26)11-23/h6-7, 9, 12, 15-16, 19, 23, 27H, 4-5, 8, 10-11H2, 1-3H3/t12-, 15-, 16-, 19+, 20-, 21-, 22-/m0/s1
SMILES Code: O=C(C=C1CC[C]2([H])[C]3([H])C[CH](C)[C](O)([C]3(C4)C)C(CO)=O)C=C[C]1(C)[C]2([H])C4=O
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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