Comparison

Bazedoxifene acetate (TSE-424)

Item no. V1734-25mg
Manufacturer InvivoChem LLC
CASRN 198481-33-3
Amount 25 mg
Quantity options 100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V1734CAS #:198481-33-3 Purity >=98%

Description: Bazedoxifene acetate (also known as TSE-424; WAY140424), a novel third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERalpha and ERbeta, respectively, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. Bazedoxifene does not stimulate ERalpha mediated transcriptional activity and acts as an antagonist to estradiol in cultured breast cancer (bMCF-7) cells. Similar results are seen in other cell lines including CHO (ovarian), HepG2 (hepatic) or GTI-7 (neuronal) with bazedoxifene having no ERalpha agonist activity and acting as an antagonist to estradiol action.

References: Clin Interv Aging. 2007 Sep; 2(3): 299–303; Endocrinology. 2005 Sep; 146(9):3999-4008.

Related CAS #: 198480-56-7 (HCl); 198481-32-2 (free base); 198481-33-3 (acetate)

Molecular Weight (MW)
507.06
Formula
C30H34N2O3.HCl
CAS No.
198481-33-3 (acetate);
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 101 mg/mL (199.12mM)
Water: < 1 mg/mL
Ethanol: N/A
Other info
Chemical Name: 1-(p-(2-(Hexahydro-1H-azepin-1-yl)ethoxy)benzyl)-2-(p-hydroxyphenyl)-3-methylindol-5-ol acetic acid
InChi Key: OMZAMQFQZMUNTP-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31; 1-2(3)4/h6-15, 20, 33-34H, 2-5, 16-19, 21H2, 1H3; 1H3, (H, 3, 4)
SMILES Code: OC1=CC2=C(C=C1)N(C(C3=CC=C(C=C3)O)=C2C)CC4=CC=C(C=C4)OCCN5CCCCCC5.CC(O)=O
Synonyms
TSE-424; WAY-140424; WAY140424; WAY 140424; TSE 424; TSE424; Viviant.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
available

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