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Description: Ethisterone is a progestogen hormone and a synthetic contraceptive that is being developed to treat prostate cancer. It is the first orally active progestin, ethisterone (pregneninolone, 17alpha-ethynyltestosterone or 19-norandrostane), the 17alpha-ethynyl analog of testosterone. Ethisterone is a progestogen that counteracts estrogenic proliferative effects on the endometrium. Ethisterone (dose range: 40 ug-5 mg/day x 6) stimulates weight gain but has a rather weak effect on the sulphate pools and incorporation rates in mice.
References: Acta Pharmacol Toxicol (Copenh). 1971; 29(23):177-93.
Chemical Name: (8R, 9S, 10R, 13S, 14S, 17R)-17-ethynyl-17-hydroxy-10, 13-dimethyl-1, 2, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key: CHNXZKVNWQUJIB-CEGNMAFCSA-N
InChi Code: InChI=1S/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14, 2)17(16)8-11-20(18, 21)3/h1, 13, 16-18, 23H, 5-12H2, 2-3H3/t16-, 17+, 18+, 19+, 20+, 21+/m1/s1
SMILES Code: O=C1CC[C]2(C)[C]3([H])CC[C]4(C)[C](C#C)(O)CC[C]4([H])[C]3([H])CCC2=C1
NSC 9565; NSC-9565; NSC9565; Aethisteron; Progestoral; Ethisterone
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