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AZD3514

AZD3514

Item no.	V1766-25mg
Manufacturer	InvivoChem LLC
CASRN	1240299-33-5
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1766CAS #:1240299-33-5Purity >=98% Description: AZD3514 is a novel, potent and orally bioavailable androgen receptor downregulator with Ki of 2.2 uM and has the ability of reducing AR protein expression and thus has the potential to be used as an anticancer agent. In LNCaP and LAPC4 prostate cancer cells, AZD3514 inhibited DHT-driven proliferation of LNCaP cells in a dose-dependent way and inhibited the ligand-driven expression of AR-regulated genes PSA and TMPRSS2. Also, AZD3514 reduced AR protein expression in a dose-dependent way. AZD3514 is being studied in a Phase I clinical trial to treat patients with castrate-resistant prostate cancer. References: Bioorg Med Chem Lett. 2013 Apr 1; 23(7):1945-8; Mol Cancer Ther. 2013 Sep; 12(9):1715-27.
Molecular Weight (MW)	519.56
Formula	C25H32F3N7O2
CAS No.	1240299-33-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (192.5 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (192.5 mM)
Other Info	Chemical Name: 1-(4-(2-(4-(1-(3-(trifluoromethyl)-7, 8-dihydro-[1, 2, 4]triazolo[4, 3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone InChi Key: JMEYDSHPKCSIJC-UHFFFAOYSA-N InChi Code: InChI=1S/C25H32F3N7O2/c1-18(36)33-14-12-32(13-15-33)16-17-37-21-4-2-19(3-5-21)20-8-10-34(11-9-20)23-7-6-22-29-30-24(25(26, 27)28)35(22)31-23/h2-5, 20H, 6-17H2, 1H3 SMILES Code: CC(N1CCN(CCOC2=CC=C(C3CCN(C4=NN5C(CC4)=NN=C5C(F)(F)F)CC3)C=C2)CC1)=O
Synonyms	AZD3514; AZD 3514; AZD-3514.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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