PD123319

Description: PD 123319 (S)-(+)-PD 123319 is a novel, potent, and selective nonpeptide AT2 (angiotensin II) receptor antagonist with IC50 of 34 nM. It displaces 125I-labeled angiotensin II from a specific subset of angiotensin II binding sites in rat adrenal preparations. PD 123319 has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models. PD-123319 is found to prevent Ang II from binding the bovine zona glomerulosa microsomal preparation with IC50 value of 6.9nM in the binding assay using microsome.

References: Mol Pharmacol. 1992 Apr; 41(4):809-15; J Renin Angiotensin Aldosterone Syst. 2001 Sep; 2(3):188-92.

Related CAS#: 136676-91-0 (ditrifluoroacetate); 130663-39-7 (free base)