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Candesartan Cilexetil (CV 11974)

Candesartan Cilexetil (CV 11974)

Item no.	V1784-1g
Manufacturer	InvivoChem LLC
CASRN	145040-37-5
Amount	1 g
Quantity options	2 g 500 mg 50 g 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1784CAS #:145040-37-5Purity >=98% Description: Candesartan Cilexetil (also known as CV-11974) is an antihypertensive drug acting as an AT II/angiotensin II receptor antagonist with IC50 of 0.26 nM. Candesartan is primarily used for the treatment of hypertension. It is marketed as the cilexetil ester, which is known as candesartan cilexetil. Candesartan cilexetil is metabolized completely by esterase in the intestinal wall during absorption to the active candesartan moiety. The use of a prodrug form increases the bioavailability of candesartan. References: Am J Health Syst Pharm. 2000 Apr 15; 57(8):739-46; Toxicology. 2012 Jan 27; 291(1-3):139-45.
Molecular Weight (MW)	610.66
Formula	C33H34N6O6
CAS No.	145040-37-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 122 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 4 mg/mL (6.6 mM)
Other info	Chemical Name: 1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1, 1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate InChi Key: GHOSNRCGJFBJIB-UHFFFAOYSA-N InChi Code: InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9, 12-19, 21, 24H, 3-6, 10-11, 20H2, 1-2H3, (H, 35, 36, 37, 38) SMILES Code: O=C(OC(C)OC(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)=O)OC6CCCCC6
Synonyms	CV-11974; CV 11974; CV11974; TCV-116; TCV 116; TCV116

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