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Exemestane (FCE 24304; EXE)

Exemestane (FCE 24304; EXE)

Item no.	V1800-10g
Manufacturer	InvivoChem LLC
CASRN	107868-30-4
Amount	10 g
Quantity options	100 mg 1 g 250 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1800CAS #:107868-30-4Purity >=98% Description: Exemestane (formerly also known as FCE24304, PNU155971; FCE 24304; EXE), a drug used in ER-positive breast cancer, is a synthetic and potent aromatase inhibitor, which inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Structurally similar to androstenedione, exemestane might have a big impact on androgenic effect. References: J Steroid Biochem Mol Biol. 1994 Jun; 49(4-6):289-94; Clin Cancer Res. 2004 Sep 1; 10(17):5717-23.
Molecular Weight (MW)	296.4
Formula	C20H24O2
CAS No.	107868-30-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 54 mg/mL (182.2 mM)
	Water: < 1 mg/mL
	Ethanol: 15 mg/mL (50.6 mM)
Other info	Chemical Name: (8R, 9S, 10R, 13S, 14S)-10, 13-dimethyl-6-methylene-7, 8, 9, 10, 11, 12, 13, 14, 15, 16-decahydro-3H-cyclopenta[a]phenanthrene-3, 17(6H)-dione. InChi Key: BFYIZQONLCFLEV-DAELLWKTSA-N InChi Code: InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15, 3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6, 8, 11, 14-16H, 1, 4-5, 7, 9-10H2, 2-3H3/t14-, 15-, 16-, 19+, 20-/m0/s1 SMILES Code: O=C(C=C1C(C[C]2([H])[C]3([H])CC4)=C)C=C[C]1(C)[C]2([H])CC[C]3(C)C4=O
Synonyms	FCE24304, PNU155971; PNU155971; PNU-155971; PNU 155971; FCE24304; FCE-24304; FCE 24304; Exemestane; US trade name: Aromasin.

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