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Dutasteride (GG 745; GI 198745)

Dutasteride (GG 745; GI 198745)

Item no.	V1808-250mg
Manufacturer	InvivoChem LLC
CASRN	164656-23-9
Amount	250 mg
Quantity options	100 mg 1 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1808CAS #:164656-23-9Purity >=98% Description: Dutasteride (also known as GI198745, GG-745; trade names: Avodart, Avidart) is a potent dual 5-alpha reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). Dutasteride inhibited conversion of 3H-testosterone to 3H-DHT by more than 99% in LNCaP cells.It can also strongly reduces growth, proliferation, and viability of LNCaP cells as well. Dutasteride increased the enzymatic activities of caspase 7 and caspase 8 dose-dependently at 48 hours, providing functional significance and confirming that the apoptotic and survival pathways are being activated by dutasteride treatment in LNCaP cells. References: Curr Top Med Chem. 2006; 6(5):405-21. Related CAS#: 164656-22-8 (Dihydro Dutasteride); 957229-52-6 (5beta-Dutasteride)
Molecular Weight (MW)	528.53
Formula	C27H30F6N2O2
CAS No.	164656-23-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 62 mg/mL (117.3 mM)
	Water: < 1 mg/mL
	Ethanol: 6 mg/mL (11.4 mM)
Other Info	Chemical Name: (4aR, 6aS, 7S, 9aS, 9bS, 11aR)-N-(2, 5-bis(trifluoromethyl)phenyl)-4a, 6a-dimethyl-2-oxo-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11, 11a-tetradecahydro-1H-indeno[5, 4-f]quinoline-7-carboxamide InChi Key: JWJOTENAMICLJG-VYZSUTEISA-N InChi Code: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17, 2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28, 29)30)3-5-18(20)27(31, 32)33/h3, 5, 10, 12-13, 15-17, 19, 21H, 4, 6-9, 11H2, 1-2H3, (H, 34, 37)(H, 35, 36)/t15-, 16-, 17?, 19+, 21+, 24-, 25+/m0/s1 SMILES Code: C[C]12CCC3[CH](CC[CH]4[C]3(C)C=CC(N4)=O)[CH]1CC[CH]2C(NC(C=C(C=C5)C(F)(F)F)=C5C(F)(F)F)=O
Synonyms	GI-198745, GG-745; GI198745, GG745; GI 198745, GG 745; LS-173584; LS 173584; LS173584; trade names: Avodart; Avidart; Avolve; Duagen; Dutas; Dutagen; Duprost.

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Amount: 250 mg

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Delivery expected until 10/2/2025

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