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BMS-707035

BMS-707035

Item no.	V1833-10mg
Manufacturer	InvivoChem LLC
CASRN	729607-74-3
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1833CAS #:729607-74-3Purity >=98% Description: BMS-707035 is a novel, potent, specific, and reversible inhibitor of HIV-I integrase (IN) with IC50 of 15 nM. BMS-707035 is an investigational IN inhibitor. However, the IN mutations V75I, Q148R, V151I, and G163R are found to have resistance to BMS-707035. The inhibition of strand transfer activity by BMS-707035 is overcome when increasing amount of target DNA, so the binding of BMS-707035 to IN and target DNA to IN are mutually exclusive. The four terminal bases at the 5' end of LTR can affect the binding of BMS-707035 to IN. References: J Biol Chem. 2007 Oct 26; 282(43):31186-96; Biochemistry. 2008 Dec 23; 47(51):13481-8.
Molecular Weight (MW)	410.42
Formula	C17H19FN4O5S
CAS No.	729607-74-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 38 mg/mL (92.6 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
SMILES	FC1=CC=C(C=C1)CNC(C(N=C(N2C)N3S(CCCC3)(=O)=O)=C(C2=O)O)=O
Synonyms	BMS-707035; BMS-707035; BMS-707035; 2-(1, 1-dioxido-1, 2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidine-4-carboxamide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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