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MK-2048

MK-2048

Item no.	V1834-10mg
Manufacturer	InvivoChem LLC
CASRN	869901-69-9
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1834CAS #:869901-69-9Purity >=98% Description: MK-2048 is a potent and second-generation inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. MK-2048 is a a second-generation HIV-1 integrase inhibitor that is the prototypical second-generation integrase strand transfer inhibitor (INSTI) developed with the goal of retaining activity against viruses containing mutations associated with resistance to first-generation INSTIs, raltegravir and elvitegravir. The inhibition activity of MK-2048 against integrase was evaluated by means of purified recombinant subtype B and C integrase enzymes. References: J Virol. 2012 Mar; 86(5):2696-705; Retrovirology. 2009 Nov 11; 6:103. doi: 10.1186/1742-4690-6-103.
Molecular Weight (MW)	461.87
Formula	C21H21ClFN5O4
CAS No.	869901-69-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 9 mg/mL (19.5 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
Other info	Chemical Name: (S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N, 6-dimethyl-1, 9-dioxo-1, 2, 6, 7, 8, 9-hexahydropyrazino[1', 2':1, 5]pyrrolo[2, 3-d]pyridazine-4-carboxamide InChi Key: JSRREMIKIHJGAA-JTQLQIEISA-N InChi Code: InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7, 10, 29H, 4, 8-9H2, 1-3H3, (H, 24, 30)/t10-/m0/s1 SMILES Code: O=C(C(C1=C2C(O)=C3N1[CH](C)CN(CC)C3=O)=NN(CC4=CC=C(F)C(Cl)=C4)C2=O)NC
Synonyms	MK2048; MK 2048; MK-2048

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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