Dabigatran (BIBR 953)

Description: Dabigatran (also known as BIBR 953 and BIBR 953ZW) is a potent, nonpeptide, reversible, selective and direct thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay. Dabigatran is designed to be converted into an orally active prodrug BIBR 1048 due to its highly polar, zwitterionic nature and poor oral absorption. Dabigatran inhibits thrombin in a competitive fashion. This inhibition is rapid and reversible. Dabigatran inhibits both clot-bound and free thrombin. Dabigatran is demonstrated to have an anticoagulant efficacy both in vitro and ex vivo.

References: J Med Chem. 2002 Apr 25; 45(9):1757-66.

Related CAS#: 211915-06-9 (Dabigatran etexilate); 872728-81-9 (Dabiga tran etexilate mesylate); 211914-50-0 (Dabigatran ethyl ester HCl); 429658-95-7 (Dabigatran ethyl ester); 212321-78-3 (BIBR 1087 SE, an intermediate metabolite of dabigatran etexilate)