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Description: Tazobactam (CL-298741; YTR-830H) is a beta-lactamase inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other beta-lactam antibiotics to broaden their spectrum and enhance their effect. Tazobactam is commonly used as its sodium salt, tazobactam sodium. Tazobactam is combined with the extended spectrum beta-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, one of the preferred antibiotic treatments for nosocomial pneumonia caused by Pseudomonas aeruginosa.
References: Drugs. 2014 Jan; 74(1):31-51; Infect Drug Resist. 2013 Nov 29; 6:215-23.
Related CAS #:89786-04-9 (free acid) 89785-84-2 (sodium)
Chemical Name: (2S, 3S, 5R)-3-((1H-1, 2, 3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4, 4-dioxide
InChi Key: LPQZKKCYTLCDGQ-WEDXCCLWSA-N
InChi Code: InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10, 18)19/h2-3, 7-8H, 4-5H2, 1H3, (H, 16, 17)/t7-, 8+, 10+/m1/s1
SMILES Code: O=C([CH]([C](CN1N=NC=C1)(C)S([C]2([H])C3)(=O)=O)N2C3=O)O
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