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Riociguat (BAY 63-2521)

Riociguat (BAY 63-2521)

Item no.	V1868-500mg
Manufacturer	InvivoChem LLC
CASRN	625115-55-1
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1868CAS #:625115-55-1 Purity >=98% Description: Riociguat (formerly also known as BAY 63-2521, and BAY 632521) is a novel, potent and oral bioavailable and soluble guanylate cyclase (GC) stimulator that is currently in clinical development. Riociguat is used in the treatment of ipulmonary hypertension. Riociguat is currently in clinical development by Bayer. The Phase III clinical trials investigated the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators. References: Eur Respir J. 2008 Oct; 32(4):881-91; Br J Pharmacol. 2015 Nov; 172(21):5199-210.
Molecular Weight (MW)	422.42
Formula	C20H19FN8O2
CAS No.	625115-55-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 50 mg/mL (118.37 mM)
	Water: < 1 mg/mL
	Ethanol: N/A
Solubility (In vivo)	IUPAC/Chemical Name: methyl (4, 6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3, 4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate InChi Key: WXXSNCNJFUAIDG-UHFFFAOYSA-N InChi Code: InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H, 10H2, 1-2H3, (H4, 22, 23, 25, 26) SMILES Code: O=C(OC)N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)C
Synonyms	BAY 63-2521; BAY63-2521; BAY632521; Trade name: Adempas

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 500 mg

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Delivery expected until 10/2/2025

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