BAY 41-2272

Description: BAY 41-2272 is a novel and potent activator of nitric oxide-sensitive guanylyl cyclase (NO-sensitive GC) with EC50 values of 0.3 umol/L and 3 umol/L in the presence and absence of 100 nmol/L DEA-NO, respectively. In platelets, GSNO at 3 umol/L (a submaximally effective concentration) was used to assess a possible sensitizing effect of BAY 41-2272 on NO-sensitive GC. The cGMP response resulted from the application of NO at this concentration in the absence of BAY 41-2272 was only marginal. In the presence of BAY 41-2272 at 100 umol/L, treatment with GSNO at 3 umol/L resulted in a rapid increase in cGMP up to 1000 pmol/109 platelets.

References: Circulation. 2004 Apr 13; 109(14):1711-3; Nature. 2001 Mar 8; 410(6825):212-5; J Urol. 2003 Feb; 169(2):761-6.